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    科研業績

    論文發表及專利申請情況(近5年,時間倒敘)

    發布時間:2020-10-27 09:51:33 瀏覽次數:
    字號:
    +-14
    瀏覽次數:

    )發表論文和專利情況

          1.Yuhui Li#, Xuan Zheng#, Dan Li, Mingyang Sun, Zhuo Wang, Jingwu Li* and Yufeng Li*. Facilitation of Temozolomide Resistance of Glioblastoma by Long Noncoding RNA DLK1-35. Iranian Red Crescent Medical Journal. 2023 May; 25(5):e2468.

          2.Yuhui Li#, Xuan Zheng#, Jangong Wang, Mingyang Sun, Dan Li, Zhuo Wang, Jingwu Li*, Yufeng Li*, Yongliang Liu*. Exosomal circ-AHCY promotes glioblastoma cell growth via Wnt/β-catenin signaling pathway. Ann Clin Transl Neurol. 2023 Jun;10(6):865-878.

          3.Shuqing Wang#, Yufeng Li#, Yudong Zhang, Dan Li, Zhuo Wang, Yanrong Zhang, Ning Zhang, Jinghua Zhang*. Effect of JMJD6 and EYA2 on modulating radio-resistance of breast cancer cells. International Journal of Human Genentics. 2023, 23(1):75-84.

          4.Yuhui Li#, Dan Li#, Yankun Liu, Shuqing Wang, Mingyang Sun, Zhongyuan Zhang, Xuan Zheng, Jingwu Li*, Yufeng Li*. The positive feedback loop of NHE1-ERK phosphorylation mediated by BRAFV600E mutation contributes to tumorigenesis and development of glioblastoma. BBRC. 2022 Jan 15;588:1-7.

    5.Cao X K,Ma Q H,Wang B,Qian Q Q,Xi Y N.Circ-E2F3 promotes cervical cancer progression by inhibiting microRNA-296-5p and increasing STAT3 nuclear translocation.[J] Ann N Y Acad Sci. 2021.

    6.Qian Q Z,Ma Q H,Wang B,Qian Q Q,Zhao C S,Feng F M,Dong X N.MicroRNA-205-5p targets E2F1 to promote autophagy and inhibit pulmonary fibrosis in silicosis through impairing SKP2-mediated Beclin1 ubiquitination[ J ]Cell Mol Med.2021.

    7.Wang p,Zhao X Q,Wu X T,Tang G S,Yuan L N.miR-15b-3p promotes the malignant progression of endometrial cancer cells through targeting KLF2[J] Cell Cycle.2021.20(14).1431-1440.

    8.Xiong w,Huang X Z,Yao S H,Wang L Q,Wang J,Wang X H.Expression of AKR1C3,beta-Catenin and LEE1in Esophageal Squamous Call Carcinoma and the Relationship with Radiation Resistance[J] Iran J Public Health.2021,50(7).1488-1490

    9.Zhang S L,Wang Y Q,Zhang J H,Hu J W,Ma J,Gu Z,Wang Y,Chen J J.Methylated p16 gene is associated with negative expression of estrogen receptor progesterone receptor and human epidermal growth factor receptor 2 in breast cancer[J] J Cancer Res Ther.2021,42(3),530-536

    10.Li Y H,Zhou Y,Liu Y Y,Zhang G J,Xiao L,Li N,Qin H F,Wang J G,Zhang L.Severe immune-related hyperthermia followed by immune-related pneumonitis with PD-1 inhibitor (sintilimab) in small cell lung cancer:A case report[J] Case Reports.2021,12(11),1780-1783.

    11.Xiong W,nHuang X Z,Hue W N.AKR1C3 and beta-catenin expression in non-small cell lung cancer and relationship with radiation resistance[J] J BUON.2021,26(3),802-811.

    12.Zhang S Y,Ding X G,Miao H X,Wang L,Xian L G,Han S G,Zhang D,Li J.The Effects of MIR-320 on the Proliferation and Differentiation of Human Alveolar Bone-Derived Mesenchymal Stem Cells.2021,11(5),937-942.

    13.Dai S,Huang Y,Liu T,Xu Z H,Liu T,Chen L,Wang Z W,Lou F.Development and validation of RNA binding protein-applied prediction model for gastric cancer[J]Aging(Albany NY).2021,13(4),5539-5552.

    14.Zhao F C,Wang Z Y,Gao Y L,Wu Y S,Liu J M,He S L.Randomized Efficacy Trial of Conventional,TCM Herb,and TEAS onBone Marrow Suppression in Patients with Small Cell Lung Cancer after lnitial Chemotherapy[J] Evid Based Complement Alternat Med.2021,2021

    15.Dong W Y,An B,Wang Y,CuiX Y,Gan J H.Effect of multimodal analgesia on gynecological cancer patients after radical resection[J] Am J Transl Res.2021,13(4)2686-2693.

    16.Zhao J,Chai G Z,Yang F J,Xu L Z,Zhao J,Wang Y P,Liu C Y.Analysis of the change of clinical nursing pathway in health education among patients with ovarian carcinoma[J] Am J Transl Res.2021,13(4),3138-3146.

    17.Dong W,Li J W,Dong X L,Shi W J,Zhang Y,Liu Y L.MiR-17 and miR-93Promote Tumor Progressio by Targeting p21 in Patients with Chordoma[J] Onco Targets Ther.2021,14,3109-3118.

    18.Li Q K, Chen J, Hu Y, H?ti N, Lih TM, Thomas SN, Chen L, Roy S, Meeker A, Shah P, Chen L, Bova GS, Zhang B, Zhang H. Proteomic characterization of primary and metastatic prostate cancer reveals reduced proteinase activity in aggressive tumors. Sci Rep[J] Sci Rep. 2021 Sep 23;11(1):18936.

    19.Wang J#, Liu Y T#, Li Y, Zheng X, Gan J H, Wan Z Y, Zhang J, Liu Y, Wang Y Q, Hu W N*, Li Y F*, Liu Y K* Exosomal-miR-10a Derived from Colorectal Cancer Cells Suppresses Migration of Human Lung Fibroblasts and Expression of IL-6, IL-8 and IL-1β[J]. Molecular Medicine Reports. 2020 Accepted.

    20.Liu Y, Zhang Y Y, Wang S Q, Li M, Long Y H, Li Y F*, Liu Y K, Li Y H, Wang Y Q, Mi J S, Yu C H, Li D Y, Zhang J H*, Zhang X J*. WSTF acetylation by MOF promotes WSTF activities and oncogenic functions[J]. Oncogene. 2020(39):5056-5067.

    21.Liu Y, Long Y H, Wang S Q, Zhang Y Y, Li Y F, Mi J S, Yu C H, Li D Y, Zhang J H*, Zhang X Z*. JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity[J]. Oncogene. 2019,38(7):980-997.

    22.Xiao J#, Liu Y K#, Wu F X #,Liu R Y#, Xie Y L, Yang Q, Li Y F, Liu M, Li S P, Tang H*. miR-639 Expression Is Silenced by DNMT3AMediated Hypermethylation and Functions as a Tumor Suppressor in Liver Cancer Cells[J]. Molecular Therapy. 2020 Feb 5;28(2):587-598.

    23.Hu Y, Wu F X, Liu Y K, Zhao Q, Tang H*. DNMT1 Recruited by EZH2-mediated Silencing of miR-484 Contributes to the Malignancy of Cervical Cancer Cells Through MMP14 and HNF1A[J]. Clinical Epigenetics. 2019,11:186.

    24.Yao L L, Zhou Y D, Sui Z H, Zhang Y L, Liu Y K, Xie H, Gao H J, Fan H X, Zhang Y, Liu M, Li S P, and Tang H. HBV-encoded miR-2 functions as an oncogene by downregulating TRIM35 but upregulating RAN in liver cancer cells[J]. EBioMedicine. 2019 Oct;48:117-129.

    25.Liu Y, Long Y H, Wang S Q, Zhang Y Y, Li Y F, Mi J S, Yu C H, Li D Y, Zhang* J H, Zhang* X J. JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity[J]. Oncogene, 2018, 38(7):980-997.

    26.Li Y F, Dong W Y, Shan X J, Hong H, Liu Y, Liu Y K, Liu S H, Zhang* X J, Zhang* J H. Anti-tumor effects of Mfn2 in breast cancer are promoter DNA methylation, P21Ras binding site and PKA phosphorylation site dependent[J]. Oncology Letters, 2018, 15(5):8011-8018.

    27.Dong W, Li J, Liu Q, Liu C, Li C, Song G, Zhu H, Gao H, Zhang Y. P21waf1/cip1 and p27kip1 are correlated with the development and invasion of prolactinoma[J]. Journal of Neuro-Oncology, 2018, 136(3):485-494.

    28.Liu M Y, Zhang Y, Zhang J, Cai H, Zhang C, Yang Z, Niu Y, Wang H, Wei X, Wang W, Gao P, Li H, Zhang J H, Sun G H. MicroRNA-1253 suppresses cellproliferation and invasion of non-small-celllung carcinoma by targeting WNT5A[J]. Cell Death and Disease, 2018, 9(2):189.

    29.He X, Chen S Y, Yang Z, Zhang J, Wang W, Liu M Y, Niu Y, Wei X M, Li H M, Sun G G, Hu W N, Sun G H. miR-4317suooresses non-snall cell lung cancer (NSCLC)bytargeting fibroblast growth factor 9(FGF9)and cyclin D2(CCND2)[J]. Journal of Experimental and Clinical Cancer Research, 2018, 37(1):230.

    30.Liu Y K, Zhanq Y N, Wu H D, Li Y F, Zhang Y, Liu M, Li X, Tang* H. miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis[J]. Cell Death and Disease, 2017, 8(4):e2739.

    31.Liu Y K, Han S G, Li Y H, Liu Y, Zhang D, Li* Y F, Zhang* J H. miR-20a contributes to cisplatin-resistance and migration of ovarian cancer cell line OVCAR3[J]. Oncology Letters, 2017, 14(2):1780-1786.

    32.Nagarajan D, Wang L, Zhao W, Han X. Trichostatin A inhibits radiation-induced epithelial-tomesenchymal transition in the alveolar epithelial cells[J]. Oncotarget, 2017, 8(60):101745-101759.

    33.Zhao Y, He J, Sun G G, Hu W. miR-769-5p suppressed cell proliferation,migration and inwasion by targeting TGFBR1 in non-small cell lung carcinoma[J]. OncotargetYang Z, He J, Gao P. miR-769-5p suppressed cell proliferation, migration and invasion by targeting TGFBR1 in non-small cell lung carcinoma[J]. Oncotarget, 2017, 8(69):113558-113570.

    34.Xu S, Tian S, Jiang C, Liu X, Zhang Z, Chen H, Zhang Y, Liu Y, Ma D. Hypermethylation of IFN-γ in oral cancer tissues[J]. Clinical Oral Investigations, 2017, 21(8):2535-2542.

    35.Gan J H, Zhao Z Y, Liu J B, Cheng Q. Clinical evaluation of combination of dexmedetomidine and midazolam vs. dexmedetomidine alone for sedation during spinal anesthesia[J]. Saudi Journal of Biological Sciences, 2017, 24(8):1758-1762.

    36.Zheng M, Zhou S, Shen Y, Wang L, Che R, Hu W, Li P. DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer[J]. Oncotarget, 2017, 8(21):34652-34660.

    37.Zheng M, Hu W, Gao H, Sun S, Wang H, Yue Z, Zhu Y, Han X, Yang J, Zhou Y, Cai Y. Chaperonin containing TCP1 subunit 5 is a tumor associated antigen of non-small cell lung cancer[J]. Oncotarget, 2017, 8(38):64170-64179.

    38.Zhao Y T, Yan J Y, Han X C, Niu F L, Zhang J H, Hu W N. Anti-proliferative effect of digoxin on breast cancer cells via inducing apoptosis[J]. European Review for Medical and Pharmacological Sciences, 2017, 21(24):5837-5842.

    39.Zhang Y, Yan J Y, Wang L, Dai H, Li N, Hu W, Cai H F. HIF-1a Promotes Breast Cancer Cell MCF-7 Proliferationand Invasion Through Regulating miR-210[J]. Cancer Biotherapy and Radiopharmaceuticals, 2017, 32(8):297-301.

    40.Yan J Y, Cai H F, Zhang J H, Zhang B, Li N, Hu W N. Treatment of breast cancer based on FOLFOX4 therapy for colon cancer: A case report[J]. Biomedical Research, 2017, 258-261.

    41.Zhang J H, Zhang T, Gao S H, Wang K, Yang X Y, Mo F F, Yu N, An T, Li Y F, Hu J W, Jiang* G J. Mitofusin-2 is required for mouse oocyte meiotic maturation, 2016, 6(1):30970.

    42.Zhang Y, Wang L, Li N, Dai H, Sun J, Cai H F. Downregulation of long non-coding RNA MALAT1 induces tumor progression of human breast cancer through regulating CCND1 expression[J]. Open Life Sciences, 2016, 11: 232–236.

    43.Yan J Y, Zhang Y. The role of miR-222 and miR-298 in breast cancer drug resistance[J]. International Journal of Clinical and Experimental Pathology, 2016, 9(10):9931-9937.

    44.Liu Y K, Guo S H, Wang L, Suzuki S, Sugimura H, Li Y F. Uterien Angiosarcoma :A Case Report and Literature Review [J]. International journal of Gynecological Pathology, 2016, 35(3):264-8.

    45.Liu X, Guan Y, Xu S, Li Q, Sun Y, Han R, Jiang C. Early Predictors of Acute Kidney Injury:A Narrative Review [J]. Kidney Blood Pressure Research, 2016, 41(5):680-700.

    46.Song H, Xiong H, Che J, Xi Q S, Huang L, Xiong H H.Gel-Based Chemical Cross-Linking Analysis of 20S Proteasome Subunit-Subunit Interactions in Brest Cancer [J]. J Huazhong University Science Technology Medical Science, 2016, 36(4):564-570.

    47.Zhao L M, Sun G G, Han L N, Liu L H, Ren F Z, Li L, Ma M, Shan B E. P-Hydroxycinnamaldehyde Induces B16-F1 Mwlanoma cell Differentiation via the RhoA-MAPK Signaling pathway [J]. Cellular Physiolgy and Biochemistry, 2016, 38(6):2247-60.

    48.Zhang J H, Zhang T, Gao S H, Wang K, Yang X Y, Mo F F, Na Yu, An T, Li Y F, Hu J W, Jiang G J. Mitofusin-2 is required for mouse oocyte meiotic maturation [J]. Scientific Reports, 2016 , 6:30970.

    49. Wang Y, Liu Y, Li Y, Zhang J, Liu Y, Li Y, Deng Y, Wang S. Williams syndrome transcription factor is a target of pro-oncogenic Ser158 phosphorylation mediated by Ras-MAPK pathway in human breast cancer [J]. International Journal of Clinical and Experimental Pathology, 2016, 9(2), 1668-1675.

    50.Liu Y, Wang S Q, Long Y H, Chen S, Li Y F, Zhang J H. KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway [J]. Oncotarget, 2016, 7(33):53153-53164.

    51.Liu Y, Long Y H, Wang S Q, Li Y F, Zhang J H. Phosphorylation of H2A.XTyr39 positively regulates DNA damage response and is linked to cancer progression [J]. FEBS Journal, 2016, 283(24):4462-4473.

    52.Xing L, Liu Z, Deng G, Wang H, Zhu Y, Shi P, Huo B, Li Y. Xanthogranulomatous prostattis with prostato-rectal fistula:a case report and revew of the literature[J]. Research and Repores in Urology, 2016, 8:165-168.


          專利

      1.實用新型專利:BAZ1B_K426hy及其多克隆抗體在制備檢測腫瘤的產品中的應用,2023年,發明人:李景武、李玉鳳、王淑青

      2.日本發明專利:一種人LINE 轉座子DNA 甲基化的ICON 探針、檢測試劑盒和應用,2023年,發明人:李玉鳳、李景武、王磊

      3.實用新型專利:一種癌細胞檢測用病理切片裝置,2021年,發明人:劉艷坤、李玉鳳、王磊


    )獲獎科技成果

    1.應用基礎研究,河北醫學科技獎一等獎,基因多態性與乳腺癌發病及藥物耐藥的關系,蔡海峰 胡萬寧 閆金銀 沈江倫 路延芹,唐山市人民醫院

    2.應用基礎研究,河北醫學科技獎一等獎,乳腺癌MRI表現與白介素-11及其受體、STAT3相關性的研究,李玉柱 韓龍才 張華 劉新唐 張海軍,唐山市人民醫院

    3.應用基礎研究,河北醫學科技獎一等獎,胸部腫瘤發生與轉移過程中microRNAs標志物研究與應用,孫國貴,高鵬,左方,張超,曹春曉,唐山市人民醫院

    4.應用基礎研究,河北醫學科技獎二等獎,NHE1在膠質瘤中的表達和活性調節機制及意義的研究,李玉輝 石文建 趙喜慶 李玉鳳 劉巖,唐山市人民醫院

    5.應用基礎研究,河北省科技進步二等獎,Mfn2、CBP等腫瘤標志物在乳腺癌、肝癌等腫瘤診療中的應用,張景華 劉巖 李玉鳳 胡萬寧 胡繼衛 劉艷坤 盛樹海 姜廣建 王雅琪 薛書霞

    6.應用基礎研究,河北醫學科技獎一等獎,聯合應用藥物對治療惡性胸腹水的臨床觀察,劉素艷 王帥 常娜 李艷艷 佟玲,唐山市人民醫院

    7.應用基礎研究,河北省科技進步一等獎,腫瘤分子診療關鍵技術研究及應用,孫國貴、胡萬寧、李玉鳳、張景華、韓曉晨、劉巖、張鈞、何喜、程云杰、路一芳

    8.應用基礎研究,河北省科技進步三等獎,星狀神經節阻滯治療乳腺癌術后并發癥的基礎與臨床研究,蔡海峰、閆金銀、侍鵬舉、張揚、路延芹

    9.應用基礎研究,唐山市科技進步二等獎,Cmet,HER2,EGFR,IGF-1R晚期胃癌表達及意義,趙郁、王軼楠、李海麗、朱曉婷、王鈞、肖建波、劉金慧、陳瑩、高秀娟

    10.應用基礎研究,河北醫學科技獎二等獎,探索有關因子在宮頸癌上皮內瘤變及宮頸癌中的表達及意義,魏璇、郭興巧、杜雪、馬雪梅、劉建榮

    11.應用基礎研究,河北醫學科技獎二等獎,天晴甘平對血液病化療肝損害療效及對細胞因子表達研究,劉東芳、趙曉亮、鄭雅珍、劉欣、甘靜

    12.應用基礎研究,河北醫學科技獎二等獎,TRAIL、FLIP、蛋白在人骨肉瘤中表達及腫瘤細胞增殖和凋亡的關系,付文娟、孫芳初、王連立、郭靜、董桂蘭

    13.應用基礎研究,河北醫學科技獎二等獎,團體心理治療對乳腺癌患者生活質量和情緒的影響,李秀玲、徐建國

    14.應用基礎研究,河北醫學科技獎三等獎,P53基因和UGT1A1基因在肺癌患者中的表達及應用,王曉紅、劉東芳、姚淑暉、趙洪煥、張曉斌

    15.應用基礎研究,河北醫學科技獎三等獎,P53基因并同期放化療局部晚期非小細胞肺癌療效觀察,楊俊泉、張曉斌、趙洪煥、李國歡、王翠蘭

    16.應用基礎研究,河北省中醫藥學會科技獎一等獎,柴胡加龍骨牡蠣湯加減方治療腫瘤后抑郁的臨床研究,王錦輝、王清賢、王建華、張璐、張麗敏、王翠君、柳靜、陳淑媛、楊俊泉

    17.應用基礎研究,河北省中醫藥學會科技獎二等獎,基于中西醫多模態信息構建放射性肺損傷預測模型,王志武、王靜怡、胡健、楊俊泉、邢影、房麗、張憲輝

    18.應用基礎研究,河北省科技進步二等獎,MnSOD等六種基因表達與六種腫瘤惡性表型形成干預的相關研究,胡萬寧、孫國貴

    19.應用基礎研究,河北醫學科技獎一等獎,蒜素衍生物對胃癌治療作用的體內體外實驗研究,閆金銀、李驥、韓龍才、胡萬寧、李寧

    20.應用基礎研究,河北醫學科技獎一等獎,Mfn2對人乳腺癌裸鼠移植瘤血管表皮生長因子受體(EGFR)影響的研究,張景華、胡繼衛、馬杰、胡萬寧、張順禮

    21.應用基礎研究,河北醫學科技獎一等獎,個性化干預對不同部位腫瘤患者疼痛及生活質量的影響,王建華、王錦輝、趙凱、王宇、劉春秋

    22.應用基礎研究,河北醫學科技獎一等獎,肺癌患者念珠菌藥物敏感性的研究及其分子流行病學特點,張玉敏、李玉柱、馬榮芬、陳暉、張尊

    23.應用基礎研究,河北醫學科技獎二等獎,KDRAQP1在非小細胞肺癌中的表達及意義,張風林、袁亞軍、付英霞、張靜、張振安

    24.應用基礎研究,河北醫學科技獎二等獎,非霍奇金淋巴瘤NF-KB、蛋白酶體的表達及相關研究,肖建波、李海麗、王學靜、王鈞、劉金慧

    25.應用基礎研究,河北醫學科技獎二等獎,放化同期治療對放療過程中腫瘤再修復再增殖的影響,王軼楠、趙郁、肖建波、李海麗、岳海淑

    26.應用基礎研究,省中醫藥學會技術二等獎,鴉膽子油乳對肺癌腦轉移的療效觀察及認知功能的影響,王曉紅、李義慧、鄭國紅、佟玲、肖磊、楊俊泉、王建功、黃曉智

     


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